Antimicrobial classifications
Antimicrobial classifications ( 11 Questions)
A nurse is caring for a client who has a viral infection. Which of the following antiviral groups bind to and inhibit viral reverse transcriptase enzyme that is essential for viral RNA synthesis? (Select all that apply)
These are examples of non-nucleoside reverse transcriptase inhibitors (NNRTIs), which bind to and inhibit viral reverse transcriptase enzyme that is essential for viral RNA synthesis. NNRTIs block reverse transcriptase by binding directly to the enzyme and prevent the completion of DNA synthesis.
These are examples of non-nucleoside reverse transcriptase inhibitors (NNRTIs), which bind to and inhibit viral reverse transcriptase enzyme that is essential for viral RNA synthesis. NNRTIs block reverse transcriptase by binding directly to the enzyme and prevent the completion of DNA synthesis.
These are examples of non-nucleoside reverse transcriptase inhibitors (NNRTIs), which bind to and inhibit viral reverse transcriptase enzyme that is essential for viral RNA synthesis. NNRTIs block reverse transcriptase by binding directly to the enzyme and prevent the completion of DNA synthesis.
Choice D is wrong because rilpivirine (Edurant) is also an NNRTI, but it does not bind to the same site as efavirenz, nevirapine and etravirine.
Choice E is wrong because nucleotide reverse transcriptase inhibitors (NRTIs) are different from NNRTIs.
These are examples of non-nucleoside reverse transcriptase inhibitors (NNRTIs), which bind to and inhibit viral reverse transcriptase enzyme that is essential for viral RNA synthesis. NNRTIs block reverse transcriptase by binding directly to the enzyme and prevent the completion of DNA synthesis.
Choice D is wrong because rilpivirine (Edurant) is also an NNRTI, but it does not bind to the same site as efavirenz, nevirapine and etravirine.
Therefore, it is not part of the same antiviral group.
Choice E is wrong because nucleotide reverse transcriptase inhibitors (NRTIs) are different from NNRTIs.
NRTIs are analogues of the natural deoxynucleotides that compete with them for incorporation into the viral DNA chain. However, NRTIs lack a 3′-hydroxyl group on the deoxyribose moiety, which results in chain termination.
NRTIs do not bind to reverse transcriptase enzyme directly like NNRTIs do.