Direct thrombin inhibitors (DTIs)
Direct thrombin inhibitors (DTIs) ( 5 Questions)
A nurse is caring for a client who has an overdose of dabigatran and is experiencing life-threatening bleeding. Which of the following drugs should the nurse anticipate administering as an antidote?
Vitamin K is wrong because it is not an antidote for dabigatran. Vitamin K is used to reverse the effect of warfarin, a vitamin K antagonist that inhibits the synthesis of clotting factors.
Protamine sulfate is wrong because it is not an antidote for dabigatran. Protamine sulfate is used to reverse the effect of heparin, an indirect thrombin inhibitor that enhances the activity of antithrombin .
• Dabigatran is a direct thrombin inhibitor that prevents the formation of blood clots.
It is used to treat atrial fibrillation, deep vein thrombosis, and pulmonary embolism. However, it can also cause bleeding complications, especially in high doses or in clients who have renal impairment, liver disease, or other risk factors.
• Idarucizumab is a monoclonal antibody that binds to dabigatran and reverses its anticoagulant effect. It is the only specific antidote for dabigatran overdose and should be administered intravenously as soon as possible.
Aminocaproic acid is wrong because it is not an antidote for dabigatran. Aminocaproic acid is used to treat bleeding caused by excessive fibrinolysis, such as in hemophilia or after surgery .
• Dabigatran is a direct thrombin inhibitor that prevents the formation of blood clots.
It is used to treat atrial fibrillation, deep vein thrombosis, and pulmonary embolism. However, it can also cause bleeding complications, especially in high doses or in clients who have renal impairment, liver disease, or other risk factors.
• Idarucizumab is a monoclonal antibody that binds to dabigatran and reverses its anticoagulant effect. It is the only specific antidote for dabigatran overdose and should be administered intravenously as soon as possible.
• Choice A. Vitamin K is wrong because it is not an antidote for dabigatran. Vitamin K is used to reverse the effect of warfarin, a vitamin K antagonist that inhibits the synthesis of clotting factors.
• Choice B. Protamine sulfate is wrong because it is not an antidote for dabigatran. Protamine sulfate is used to reverse the effect of heparin, an indirect thrombin inhibitor that enhances the activity of antithrombin .
• Choice D. Aminocaproic acid is wrong because it is not an antidote for dabigatran. Aminocaproic acid is used to treat bleeding caused by excessive fibrinolysis, such as in hemophilia or after surgery .
Thrombolytic agents: