Choice A rationale:

 "During latent infection, the virus replicates actively in the skin." This statement is incorrect.

During the latent infection phase of HSV, the virus remains dormant in sensory ganglia and does not actively replicate in the skin.

Choice B rationale:

 "Latent infection occurs when the virus travels along sensory nerves to sensory ganglia." This statement is correct.

During the latent infection phase, HSV travels along sensory nerves to sensory ganglia, where it remains in a dormant state.

Choice C rationale:

 "Latent infection is the phase where recurrent outbreaks of symptoms are most likely." This statement is incorrect.

Latent infection is characterized by the absence of symptoms.

Recurrent outbreaks occur during the reactivation phase, not during latency.

Choice D rationale:

 "Reactivation of the virus occurs during the initial infection." This statement is incorrect.

Reactivation of the virus typically occurs after the initial infection and during the latent phase when the virus becomes active again.