Introduction
Introduction ( 5 Questions)
A nurse is reviewing the medication history of a client who is prescribed cilostazol, an antiplatelet drug, for intermittent claudication. The nurse should recognize that which of the following medications is contraindicated with cilostazol?
Omeprazole, a proton pump inhibitor, is contraindicated with cilostazol, an antiplatelet drug, for intermittent claudication.
This is because omeprazole can inhibit the metabolism of cilostazol by affecting the hepatic/intestinal enzyme CYP2C19, which is responsible for converting cilostazol to its active metabolites. This can result in increased plasma levels of cilostazol and increased risk of bleeding and adverse effects.
Choice B is wrong because metoprolol, a beta blocker, is not contraindicated with cilostazol. Metoprolol can be used to treat hypertension, angina, and heart failure, which are common comorbidities in patients with intermittent claudication. Metoprolol does not interact significantly with cilostazol or affect its metabolism.
Choice C is wrong because simvastatin, a statin, is not contraindicated with cilostazol. Simvastatin can be used to lower cholesterol and prevent cardiovascular events in patients with intermittent claudication. Simvastatin does not interact significantly with cilostazol or affect its metabolism.
Choice D is wrong because glyburide, a sulfonylurea, is not contraindicated with cilostazol. Glyburide can be used to treat type 2 diabetes mellitus, which is a common risk factor for intermittent claudication. Glyburide does not interact significantly with cilostazol or affect its metabolism.
Omeprazole, a proton pump inhibitor, is contraindicated with cilostazol, an antiplatelet drug, for intermittent claudication.
This is because omeprazole can inhibit the metabolism of cilostazol by affecting the hepatic/intestinal enzyme CYP2C19, which is responsible for converting cilostazol to its active metabolites. This can result in increased plasma levels of cilostazol and increased risk of bleeding and adverse effects.
Choice B is wrong because metoprolol, a beta blocker, is not contraindicated with cilostazol.
Metoprolol can be used to treat hypertension, angina, and heart failure, which are common comorbidities in patients with intermittent claudication. Metoprolol does not interact significantly with cilostazol or affect its metabolism.
Choice C is wrong because simvastatin, a statin, is not contraindicated with cilostazol.
Simvastatin can be used to lower cholesterol and prevent cardiovascular events in patients with intermittent claudication. Simvastatin does not interact significantly with cilostazol or affect its metabolism.
Choice D is wrong because glyburide, a sulfonylurea, is not contraindicated with cilostazol.
Glyburide can be used to treat type 2 diabetes mellitus, which is a common risk factor for intermittent claudication. Glyburide does not interact significantly with cilostazol or affect its metabolism.