Numbness, tingling, or pain in the extremities are signs of sensory neuropathy, which is a common and dosedependent side effect of docetaxel³. Sensory neuropathy affects the nerves that carry sensations such as touch, temperature, and pain from the skin to the brain. It usually starts in the toes and fingers and may spread to the arms and legs.

Hearing loss, tinnitus, or vertigo are not directly related to docetaxel use, but may indicate other conditions such as ototoxicity, infection, or Meniere's disease. Ototoxicity is damage to the inner ear caused by certain drugs or chemicals that can affect hearing and balance. Infection is inflammation of the ear canal or middle ear that can cause pain, fever, and hearing problems. Meniere's disease is a disorder of the inner ear that causes episodes of vertigo, tinnitus, and hearing loss.

Constipation, urinary retention, or abdominal distension are not directly related to docetaxel use, but may indicate other conditions such as dehydration, bowel obstruction, or bladder dysfunction. Dehydration is loss of body fluids and electrolytes that can affect bowel movements and urination. Bowel obstruction is a blockage of the intestine that can cause abdominal pain, nausea, vomiting, and constipation. Bladder dysfunction is a problem with the muscles or nerves that control urination that can cause difficulty emptying the bladder or leaking urine.

Blurred vision, photophobia, or eye irritation are not directly related to docetaxel use, but may indicate other conditions such as ocular toxicity, infection, or allergy. Ocular toxicity is damage to the eyes caused by certain drugs or chemicals that can affect vision and eye health. Infection is inflammation of the eye or eyelid that can cause redness, discharge, and pain. Allergy is a hypersensitivity reaction to a substance that can cause itching, swelling, and tearing of the eyes.

Muscle weakness, ataxia, or seizures are signs of motor neuropathy or central nervous system toxicity, which are rare but serious side effects of docetaxel³. Motor neuropathy affects the nerves that control movement and coordination of the muscles. Central nervous system toxicity affects the brain and spinal cord and can cause confusion, hallucinations, coma, or death.