Nursing considerations for NSAIDs
Nursing considerations for NSAIDs ( 4 Questions)
A nurse is administering fludrocortisone (Florinef), a mineralocorticoid, to a client who has Addison's disease. What are some of the expected pharmacologic effects of fludrocortisone in this condition?
Fludrocortisone, a mineralocorticoid, is used in the treatment of Addison's disease, a condition characterized by adrenal insufficiency. The primary pharmacologic effects of fludrocortisone in this condition are related to its mineralocorticoid activity. It promotes sodium reabsorption and potassium excretion in the kidney, increasing blood volume and blood pressure: Fludrocortisone acts on the kidneys to enhance the reabsorption of sodium and increase the excretion of potassium. This action helps to regulate electrolyte balance and fluid volume, which can contribute to an increase in blood volume and blood pressure.
It reduces inflammation, pain, fever, and allergic reactions by inhibiting the synthesis of prostaglandins and leukotrienes: This statement describes the pharmacologic effects of glucocorticoids, not mineralocorticoids like fludrocortisone. While fludrocortisone may have some mild anti-inflammatory effects, its primary role is related to electrolyte and fluid balance rather than inflammation modulation.
It regulates the secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary gland, maintaining the feedback loop of cortisol production: This statement describes the role of cortisol, not fludrocortisone. Fludrocortisone primarily acts as a synthetic mineralocorticoid and does not directly regulate ACTH secretion or cortisol production.
It influences the carbohydrate, protein, and fat metabolism in various tissues, increasing blood glucose and suppressing immune response: This statement describes the pharmacologic effects of glucocorticoids like cortisol, not mineralocorticoids. Fludrocortisone has minimal impact on carbohydrate, protein, and fat metabolism and does not exert significant immunosuppressive effects.
Fludrocortisone, a mineralocorticoid, is used in the treatment of Addison's disease, a condition characterized by adrenal insufficiency. The primary pharmacologic effects of fludrocortisone in this condition are related to its mineralocorticoid activity. It promotes sodium reabsorption and potassium excretion in the kidney, increasing blood volume and blood pressure: Fludrocortisone acts on the kidneys to enhance the reabsorption of sodium and increase the excretion of potassium. This action helps to regulate electrolyte balance and fluid volume, which can contribute to an increase in blood volume and blood pressure.
The other options are incorrect because:
B. It reduces inflammation, pain, fever, and allergic reactions by inhibiting the synthesis of prostaglandins and leukotrienes: This statement describes the pharmacologic effects of glucocorticoids, not mineralocorticoids like fludrocortisone. While fludrocortisone may have some mild anti-inflammatory effects, its primary role is related to electrolyte and fluid balance rather than inflammation modulation.
C. It regulates the secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary gland, maintaining the feedback loop of cortisol production: This statement describes the role of cortisol, not fludrocortisone. Fludrocortisone primarily acts as a synthetic mineralocorticoid and does not directly regulate ACTH secretion or cortisol production.
D. It influences the carbohydrate, protein, and fat metabolism in various tissues, increasing blood glucose and suppressing immune response: This statement describes the pharmacologic effects of glucocorticoids like cortisol, not mineralocorticoids. Fludrocortisone has minimal impact on carbohydrate, protein, and fat metabolism and does not exert significant immunosuppressive effects.
