Choice A rationale:

Osteosarcoma arises from mature bone-forming cells called osteocytes.

Rationale: This statement is not accurate.

Osteosarcoma does not originate from osteocytes.

Instead, it arises from osteoblasts, which are immature bone-forming cells.

Genetic mutations can lead to uncontrolled proliferation of osteoblasts, contributing to the development of Osteosarcoma.

Choice B rationale:

Genetic mutations leading to uncontrolled proliferation of osteoblasts contribute to Osteosarcoma.

Rationale: This statement is accurate.

Osteosarcoma is characterized by genetic mutations that cause osteoblasts to multiply uncontrollably, resulting in the formation of malignant bone tumors.

This is a key aspect of the disease's pathophysiology.

Choice C rationale:

Osteosarcoma typically starts in the epiphyseal region of long bones.

Rationale: This statement is not accurate.

Osteosarcoma usually begins in the metaphyseal region of long bones, not the epiphyseal region.

The metaphysis is the area of the bone where growth occurs, making it more susceptible to malignant changes.

Choice D rationale:

The tumor primarily extends into the muscle tissues surrounding the bone.

Rationale: This statement is not accurate.

Osteosarcoma primarily affects the bone itself, with the tumor originating within the bone tissue.

While it can extend into nearby soft tissues, such as muscles, it does not primarily start in muscle tissues.