Choice A rationale:

Acetaminophen is indicated for mild to moderate pain and fever.

Acetaminophen is an analgesic and antipyretic medication commonly used to relieve mild to moderate pain and reduce fever.

It is suitable for various pediatric conditions, making it a valid choice for pain management in children.

Choice B rationale:

NSAIDs are contraindicated in patients with known hypersensitivity to NSAIDs, active bleeding, and renal impairment.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) can cause adverse effects, including gastrointestinal bleeding, and should be avoided in patients with active bleeding.

Additionally, patients with known hypersensitivity to NSAIDs or renal impairment are at an increased risk of experiencing side effects when taking these medications, making choice B accurate.

Choice C rationale:

Opioids work by increasing blood flow to the affected area.

This statement is incorrect.

Opioids work by binding to opioid receptors, altering the perception and response to painful stimuli.

They do not increase blood flow to the affected area.

Opioids are central nervous system depressants that act on the brain and spinal cord to modify the perception of pain.

Choice D rationale:

The dosage of Acetaminophen and NSAIDs is based on age.

This statement is partially accurate.

While age can be a factor in determining the appropriate dosage of these medications in pediatric patients, it is not the sole determinant.

Weight and specific patient characteristics may also play a role in dosing decisions.

Choice E rationale:

Opioids work by binding to opioid receptors, altering perception and response to painful stimuli.

This statement is accurate.

Opioids are a class of medications that act on specific receptors in the central nervous system, altering the perception of pain and the body's response to painful stimuli.

They do not increase blood flow to the affected area but instead modulate pain at the neurological level.