Drug Interactions > Pharmacology
Exam Review
Factors Affecting Drug Interactions
Total Questions : 10
Showing 10 questions, Sign in for moreA nurse is reviewing a client’s medication regimen and notes that the client is taking two medications with similar pharmacological actions. The nurse should recognize that this can result in which of the following?
Explanation
When two medications with similar pharmacological actions are taken together, their effects can be additive, resulting in an increased therapeutic effect.
a. An increased therapeutic effect can occur because the combined effect of the two medications is greater than the effect of either medication alone.
b. A decreased therapeutic effect is not likely to occur because the combined effect of the two medications is greater than the effect of either medication alone.
c. No change in therapeutic effect is not likely to occur because the combined effect of the two medications is greater than the effect of either medication alone.
d. An increased risk of adverse effects can occur if the combined effect of the two medications results in excessive drug action.
A nurse is reviewing a client’s medication regimen and notes that the client is taking two medications with opposing pharmacological actions. The nurse should recognize that this can result in which of the following?
Explanation
When two medications with opposing pharmacological actions are taken together, their effects can be antagonistic, resulting in a decreased therapeutic effect.
a. An increased therapeutic effect is not likely to occur because the opposing actions of the two medications can cancel each other out.
b. A decreased therapeutic effect can occur because the opposing actions of the two medications can cancel each other out.
c. No change in therapeutic effect is not likely to occur because the opposing actions of the two medications can cancel each other out.
d. An increased risk of adverse effects is not likely to occur because the opposing actions of the two medications can cancel each other out.
A nurse is preparing to administer medication to a client who has a history of drug allergies. The nurse should be aware that this can increase the client’s risk for which of the following?
Explanation
A history of drug allergies can increase a client’s risk for adverse drug reactions because allergic reactions are a type of adverse drug reaction.
a. Drug-drug interactions are not directly related to a history of drug allergies.
b. Drug-disease interactions are not directly related to a history of drug allergies.
c. Drug-food interactions are not directly related to a history of drug allergies.
d. Adverse drug reactions can occur as a result of an allergic reaction to a medication.
A patient has been prescribed two drugs with one being an agonist and another being an antagonist at the same receptor. What will be their combined effect?
Explanation
An antagonist will decrease an agonist’s action by competing for binding at the same receptor.
a. Increasing agonist’s action will not occur as an antagonist will decrease an agonist’s action by competing for binding at the same receptor.
b. Decreasing agonist’s action will occur due to competition for binding at the same receptor by an antagonist.
c. No change will not occur as an antagonist will decrease an agonist’s action by competing for binding at the same receptor.
d. Increasing antagonist’s action will not occur as an antagonist will decrease an agonist’s action by competing for binding at the same receptor.
A patient has been prescribed two drugs with one being an agonist and another being an inverse agonist at the same receptor. What will be their combined effect?
Explanation
An inverse agonist will decrease an agonist’s action by competing for binding at the same receptor and producing an opposite response.
a. Increasing agonist’s action will not occur as an inverse agonist will decrease an agonist’s action by competing for binding at the same receptor and producing an opposite response.
b. Decreasing agonist’s action will occur due to competition for binding at the same receptor by an inverse agonist and producing an opposite response.
c. No change will not occur as an inverse agonist will decrease an agonist’s action by competing for binding at the same receptor and producing an opposite response.
d. Increasing the inverse agonist’s action will not occur as an inverse agonist will decrease an agonist’s action by competing for binding at the same receptor and producing an opposite response.
A patient has been prescribed two drugs with one being an agonist and another being a partial agonist at the same receptor. What will be their combined effect?
Explanation
A partial agonist will decrease an agonist’s action by competing for binding at the same receptor and producing a submaximal response.
a. Increasing agonist’s action will not occur as a partial agonist will decrease an agonist’s action by competing for binding at the same receptor and producing a submaximal response.
b. Decreasing agonist’s action will occur due to competition for binding at the same receptor by a partial agonist and producing a submaximal response.
c. No change will not occur as a partial agonist will decrease an agonist’s action by competing for binding at the same receptor and producing a submaximal response.
d. Increasing partial agonist’s action will not occur as a partial agonist will decrease an agonist’s action by competing for binding at the same receptor and producing a submaximal response.
A patient has been prescribed two drugs with one being an antagonist and another being a partial agonist at the same receptor. What will be their combined effect?
Explanation
An antagonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.
a. Increasing the antagonist’s action will not occur as an antagonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.
b. Decreasing the antagonist’s action will not occur as an antagonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.
c. No change will not occur as an antagonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.
d. Increasing partial agonist’s action will occur due to competition for binding at the same receptor by an antagonist and decreasing the basal activity.
A patient has been prescribed two drugs with one being an inverse agonist and another being a partial agonist at the same receptor. What will be their combined effect?
Explanation
An inverse agonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.
a. Increasing inverse agonist’s action will not occur as an inverse agonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.
b. Decreasing the inverse agonist’s action will not occur as an inverse agonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.
c. No change will not occur as an inverse agonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.
d. Increasing partial agonist’s action will occur due to competition for binding at the same receptor by an inverse agonist and decreasing the basal activity.
A patient has been prescribed two drugs with one being an antagonist and another being an inverse agonist at the same receptor. What will be their combined effect?
Explanation
An antagonist and an inverse agonist will have no combined effect as they both decrease the basal activity of the receptor.
a. Increasing antagonist action will not occur as both drugs decrease the basal activity of the receptor.
b. Decreasing antagonist action will not occur as both drugs decrease the basal activity of the receptor.
c. No change in effect will occur as both drugs decrease the basal activity of the receptor.
d. Increasing inverse agonist action will not occur as both drugs decrease the basal activity of the receptor.
A patient has been prescribed two drugs with one being an agonist and another being an antagonist at different receptors. What will be their combined effect?
Explanation
An agonist and an antagonist at different receptors will have no combined effect as they act on different receptors.
a. Additive effect will not occur as both drugs act on different receptors.
b. Synergistic effect will not occur as both drugs act on different receptors.
c. Antagonistic effect will not occur as both drugs act on different receptors.
d. No change in effect will occur as both drugs act on different receptors.
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