Prenatal Diagnostic Tests And Procedures > Maternal & Newborn
Exam Review
Maternal Serum Alpha-Fetoprotein (MSAFP) Test
Total Questions : 5
Showing 5 questions, Sign in for moreA nurse is explaining the purpose of the Maternal Serum Alpha-Fetoprotein (MSAFP) test to a pregnant client.
What does this test primarily detect?
Explanation
This is because the Maternal Serum Alpha-Fetoprotein (MSAFP) test primarily detects the level of alpha-fetoprotein (AFP) in the blood of a pregnant person.AFP is a protein that a developing baby makes and normally passes into the mother’s bloodstream.Too much AFP may indicate that the baby has a neural tube defect or an abdominal wall defect, which are conditions that cause abnormal development of the baby’s body.An abdominal wall defect is a hole in the muscles and skin that cover the abdomen, which allows some of the baby’s organs to protrude outside the body.
Choice A is wrong because renal anomalies are not detected by the MSAFP test.Renal anomalies are problems with the kidneys or urinary tract of the baby.
Choice B is wrong because fetal growth and development are not detected by the MSAFP test.Fetal growth and development are assessed by other prenatal tests, such as ultrasound scans.
Choice C is wrong because chromosomal abnormalities are not detected by the MSAFP test alone.Chromosomal abnormalities are genetic disorders that affect the number or structure of the chromosomes in the baby’s cells.The MSAFP test may be combined with other tests, such as hCG, estriol, and inhibin-A, to form a quadruple screening test (or quad screen) that can check the baby’s risk of chromosomal abnormalities, such as Down syndrome.
However, the MSAFP test by itself cannot detect these conditions.
Normal ranges for MSAFP levels vary depending on the gestational age of the baby and the laboratory that performs the test.Generally, MSAFP levels increase until about 32 weeks of pregnancy and then decrease until delivery.
The normal range for MSAFP levels at 16 weeks of pregnancy
A client is scheduled to undergo the MSAFP test.
When is this test typically performed?
Explanation
This is because the maternal serum alpha-fetoprotein (MSAFP) test is a screening tool indicated for all high-risk pregnant clients between 15 and 20 weeks gestation.The test measures the level of alpha-fetoprotein (AFP) in the mother’s blood, which is produced by the fetus and can indicate certain birth defects or chromosomal abnormalities.
Choice A is wrong because the MSAFP test is not done during the first trimester of pregnancy.The first trimester screening usually includes a nuchal translucency screening, which measures the fluid at the back of the fetus’s neck to assess the risk of Down syndrome.
Choice B is wrong because the MSAFP test is not done between 11 and 14 weeks of gestation.
This is too early to detect the level of AFP in the mother’s blood.The MSAFP test is most accurate between 16 and 18 weeks of pregnancy.
Choice D is wrong
A nurse is reviewing the MSAFP test results with a client.
A high level of MSAFP (>2.5 MoM) may indicate which of the following conditions?
Explanation
A high level of MSAFP (>2.5 MoM) may indicate that the fetus has a neural tube defect such as spina bifida, which results from incomplete development of the brain and spinal cord.A neural tube defect causes an opening in the head, spine, or stomach wall that allows high levels of AFP to enter the mother’s blood.
Choice A is wrong because chromosomal abnormalities such as Down syndrome are associated with low levels of MSAFP, not high levels.Chromosomal abnormalities involve an extra or missing chromosome that affects the fetus’s development.
Choice B is wrong because fetal demise or death is not related to MSAFP levels.
Fetal demise can be caused by various factors such as infections, placental problems, or umbilical cord accidents.
Choice D is wrong because multiple gestation or having more than one fetus can also cause low levels of MSAFP, not high levels.
Multiple gestation increases the risk of complications such as preterm labor, preeclampsia, and fetal growth restriction.
Normal ranges for MSAFP vary depending on the gestational age of the fetus and the laboratory methods used.Generally, the normal range for MSAFP at 15 to 21 weeks’ gestation is 10 to 150 ng/mL.
A pregnant client asks the nurse about the risks associated with the MSAFP test.
What is the nurse's best response?
Explanation
The MSAFP test is a screening test that measures the amount of alpha-fetoprotein (AFP) in the mother’s blood.
AFP is a protein produced by the baby during pregnancy.The test helps to assess the baby’s risk of certain birth defects, such as neural tube defects or chromosomal abnormalities.
A.“The MSAFP test carries a risk of miscarriage.” This statement is wrong because the MSAFP test is a blood test that does not involve any invasive procedures or harm to the baby.
C. “The MSAFP test may cause harm to the fetus.” This statement is wrong because the MSAFP test does not affect the fetus in any way.It only measures the amount of AFP in the mother’s blood.
D. “Pregnant individuals should avoid the MSAFP test due to potential radiation exposure.” This statement is wrong because the MSAFP test does not involve any radiation exposure.It is a simple blood test that uses a needle to draw blood from a vein.
The normal range of MSAFP levels varies depending on the gestational age of the baby and the laboratory methods used.Generally, the MSAFP levels increase until about 15 weeks of pregnancy and then decrease until delivery.The average MSAFP level at 16 weeks of pregnancy is about 44 ng/mL.However, different laboratories may have different reference ranges, so it is important to consult your healthcare provider for your specific results and interpretation.
A nurse is providing education to a client about the MSAFP test.
Which of the following statements accurately describes the MSAFP results?
Explanation
This is because MSAFP is a screening test that measures the level of alpha-fetoprotein (AFP) in the maternal blood, which is produced by the fetus.The MoM value compares the AFP level of the mother to the average level for women of the same gestational age.A MoM value that is too high or too low may indicate a risk of certain fetal anomalies, such as neural tube defects or chromosomal abnormalities.
However, MSAFP results are not diagnostic and do not confirm the presence or absence of any condition.They only indicate the need for further testing, such as ultrasound, amniocentesis, or chorionic villus sampling.
Choice A is wrong because MSAFP results are not diagnostic and do not confirm the presence of fetal anomalies.They only indicate the risk of certain conditions and the need for further evaluation.
Choice B is wrong because MSAFP results require further evaluation or testing if they are abnormal.A normal MSAFP result does not rule out the possibility of fetal anomalies, nor does it guarantee a healthy outcome.
Choice D is wrong because MSAFP results do not indicate the gestational age of the fetus.They are compared to the average level for women of the same gestational age to calculate the MoM value.Gestational age can be estimated by other methods, such as ultrasound or last menstrual period.
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