Sublingual and buccal drug administration has a rapid onset of action because drugs are absorbed directly into the bloodstream through the mucous membranes under the tongue or in the cheek. This route of administration is convenient and easy to use because it does not require any special equipment or training and can be self-administered by patients. Sublingual and buccal drug administration also bypass first-pass metabolism because drugs are absorbed directly into the bloodstream, bypassing the liver.

Nitroglycerin is commonly administered sublingually for the treatment of angina pectoris. This route of administration allows for rapid absorption and onset of action.

b. Furosemide is commonly administered orally or intravenously, not sublingually.

c. Metoprolol is commonly administered orally, not sublingually.

d. Simvastatin is commonly administered orally, not sublingually.

Sublingual and buccal drug administration has a limited surface area for drug absorption, which can limit the amount of drug that can be absorbed and may affect the effectiveness of the drug.

a. Sublingual and buccal drug administration have a rapid, not slow, onset of action.

b. Sublingual and buccal drug administration is convenient and easy to use, not inconvenient and difficult to use.

d. Sublingual and buccal drug administration bypass first-pass metabolism, they do not undergo it.

Drugs administered sublingually or buccally are absorbed directly into the bloodstream through the mucous membranes under the tongue or in the cheek, bypassing the gastrointestinal tract and first-pass metabolism.

a. This statement is false because drugs administered sublingually or buccally are not swallowed and absorbed in the gastrointestinal tract.

c. This statement is false because sublingual and buccal drug administration has a faster onset of action compared to oral administration.

d. This statement is false because sublingual and buccal drug administration are non-invasive routes of administration.

Drugs that are poorly soluble in water may not be effectively absorbed through mucous membranes when administered sublingually or buccally. Drugs that have a bitter taste may be unpleasant for patients when administered sublingually or buccally.