Adverse effects and toxicity
Adverse effects and toxicity ( 5 Questions)
A nurse is caring for a client who has tuberculosis and is receiving isoniazid (INH), rifampin (Rifadin), pyrazinamide (PZA), and ethambutol (Myambutol).
The nurse monitors the client’s liver function tests and advises the client to avoid which substance while taking these drugs?
The patient should avoid alcohol while taking these drugs because alcohol can increase the risk of liver toxicity. These drugs are metabolized by the liver and can cause hepatotoxicity, especially isoniazid and pyrazinamide. The nurse should monitor the patient’s liver function tests and advise the patient to report any signs of liver damage, such as dark urine, fatigue, or jaundice.
Choice B is wrong because Grapefruit juice is wrong because grapefruit juice does not interact with these drugs.
Grapefruit juice can affect the metabolism of some other drugs, such as statins, calcium channel blockers, or cyclosporine, but not antitubercular drugs.
Choice C is wrong because Milk is wrong because milk does not interact with these drugs.
Milk can reduce the absorption of some other drugs, such as tetracyclines or fluoroquinolones, but not antitubercular drugs.
Choice D is wrong because Caffeine is wrong because caffeine does not interact with these drugs.
Caffeine can increase the effects of some other drugs, such as theophylline or clozapine, but not antitubercular drugs.
The patient should avoid alcohol while taking these drugs because alcohol can increase the risk of liver toxicity. These drugs are metabolized by the liver and can cause hepatotoxicity, especially isoniazid and pyrazinamide. The nurse should monitor the patient’s liver function tests and advise the patient to report any signs of liver damage, such as dark urine, fatigue, or jaundice.
Choice B is wrong because Grapefruit juice is wrong because grapefruit juice does not interact with these drugs.
Grapefruit juice can affect the metabolism of some other drugs, such as statins, calcium channel blockers, or cyclosporine, but not antitubercular drugs.
Choice C is wrong because Milk is wrong because milk does not interact with these drugs.
Milk can reduce the absorption of some other drugs, such as tetracyclines or fluoroquinolones, but not antitubercular drugs.
Choice D is wrong because Caffeine is wrong because caffeine does not interact with these drugs.
Caffeine can increase the effects of some other drugs, such as theophylline or clozapine, but not antitubercular drugs.