Antipsychotics
Antipsychotics ( 11 Questions)
A nurse is educating a client about the two main types of antipsychotics. Select all that apply:
First-generation antipsychotics have a high affinity for dopamine D2 receptors and a low affinity for serotonin 5-HT2A receptors. This means that they block more dopamine and less serotonin in the brain, which increases the risk of extrapyramidal side effects and does not improve negative symptoms of schizophrenia.
Second-generation antipsychotics have a low affinity for dopamine D2 receptors and a high affinity for serotonin 5-HT2A receptors. This means that they block less dopamine and more serotonin in the brain, which reduces the risk of extrapyramidal side effects and improves negative symptoms of schizophrenia.
It is the opposite of choice A. First-generation antipsychotics do not have a low affinity for dopamine D2 receptors and a high affinity for serotonin 5-HT2A receptors.
It is the opposite of choice B. Second-generation antipsychotics do not have a high affinity for dopamine D2 receptors and a low affinity for serotonin 5-HT2A receptors.
Both first-generation and second-generation antipsychotics do not have a high affinity for both dopamine D2 and serotonin 5-HT2A receptors. They have different affinities for these receptors, which account for their different effects and side effects.
Second-generation antipsychotics have a low affinity for dopamine D2 receptors and a high affinity for serotonin 5-HT2A receptors. This means that they block less dopamine and more serotonin in the brain, which reduces the risk of extrapyramidal side effects and improves negative symptoms of schizophrenia.
Choice A is wrong because first-generation antipsychotics have a high affinity for dopamine D2 receptors and a low affinity for serotonin 5-HT2A receptors. This means that they block more dopamine and less serotonin in the brain, which increases the risk of extrapyramidal side effects and does not improve negative symptoms of schizophrenia.
Choice C is wrong because it is the opposite of choice A. First-generation antipsychotics do not have a low affinity for dopamine D2 receptors and a high affinity for serotonin 5-HT2A receptors.
Choice D is wrong because it is the opposite of choice B. Second-generation antipsychotics do not have a high affinity for dopamine D2 receptors and a low affinity for serotonin 5-HT2A receptors.
Choice E is wrong because both first-generation and second-generation antipsychotics do not have a high affinity for both dopamine D2 and serotonin 5-HT2A receptors. They have different affinities for these receptors, which account for their different effects and side effects.