ATI PN Custom Pharmacology
ATI PN Custom Pharmacology ( 40 Questions)
Which difference in pharmacokinetics does the nurse expect in the obese patient as compared with the thin patient with administration of a highly lipid-soluble drug?.
Drug distribution will not necessarily be more rapid in an obese patient. The distribution depends on the volume of distribution of the drug and the body composition.
Drug metabolism may not be incomplete in an obese patient. It depends on various factors including liver function.
Drug absorption is not typically impaired in obese patients.
Drug elimination can be slowed in obese patients, especially for lipid-soluble drugs. This is because the increased fat stores in obese patients can serve as a reservoir for lipid-soluble drugs, slowing their elimination. So, the correct answer is Choice C, Drug elimination will be slowed.
Choice A rationale:
Drug distribution will not necessarily be more rapid in an obese patient. The distribution depends on the volume of distribution of the drug and the body composition.
Choice B rationale:
Drug metabolism may not be incomplete in an obese patient. It depends on various factors including liver function.
Choice C rationale:
Drug absorption is not typically impaired in obese patients.
Choice D rationale:
Drug elimination can be slowed in obese patients, especially for lipid-soluble drugs. This is because the increased fat stores in obese patients can serve as a reservoir for lipid-soluble drugs, slowing their elimination. So, the correct answer is Choice C, Drug elimination will be slowed.