Causes and risk factors
Causes and risk factors ( 7 Questions)
A nurse is teaching a client who has a new prescription for warfarin about potential drug interactions. Which of the following over-the-counter medications should the nurse instruct the client to avoid?
is incorrect because acetaminophen is an analgesic and antipyretic that does not affect platelet function or warfarin metabolism. However, high doses or chronic use of acetaminophen can increase INR and cause liver toxicity, so the nurse should advise the client to limit acetaminophen intake and monitor liver function tests.
Rationale: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of bleeding when taken with warfarin, which is an anticoagulant. NSAIDs inhibit platelet aggregation and interfere with warfarin metabolism, leading to increased levels of warfarin and prolonged prothrombin time (PT) and international normalized ratio (INR).
is incorrect because loratadine is an antihistamine that does not interact with warfarin or affect bleeding. Loratadine can be used safely by clients who have allergies and are taking warfarin.
is incorrect because calcium carbonate is an antacid and a calcium supplement that does not interact with warfarin or affect bleeding. However, calcium carbonate can interfere with the absorption of other medications, so the nurse should instruct the client to take it at least 2 hours before or after other medications.
Rationale: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of bleeding when taken with warfarin, which is an anticoagulant. NSAIDs inhibit platelet aggregation and interfere with warfarin metabolism, leading to increased levels of warfarin and prolonged prothrombin time (PT) and international normalized ratio (INR).
A) is incorrect because acetaminophen is an analgesic and antipyretic that does not affect platelet function or warfarin metabolism. However, high doses or chronic use of acetaminophen can increase INR and cause liver toxicity, so the nurse should advise the client to limit acetaminophen intake and monitor liver function tests.
C) is incorrect because loratadine is an antihistamine that does not interact with warfarin or affect bleeding. Loratadine can be used safely by clients who have allergies and are taking warfarin.
D) is incorrect because calcium carbonate is an antacid and a calcium supplement that does not interact with warfarin or affect bleeding. However, calcium carbonate can interfere with the absorption of other medications, so the nurse should instruct the client to take it at least 2 hours before or after other medications.