A) This choice is incorrect because advanced age is a non-modifiable risk factor for DVT. While age is associated with increased risk, it is not directly related to the client's use of hormonal therapy.

B) This choice is incorrect because male gender is not a risk factor for DVT. Women, particularly those on estrogen-based therapies like hormone replacement therapy or oral contraceptives, are at higher risk.

C) This choice is incorrect because smoking history is a modifiable risk factor for DVT, not directly related to hormonal therapy. Smoking increases the risk of clot formation and is not specific to the client's use of hormonal therapy.

D) This choice is correct. Estrogen-based hormone replacement therapy and oral contraceptives can increase the risk of DVT due to their effect on blood coagulation. Estrogen can increase the production of certain clotting factors, raising the risk of blood clot formation in the veins. It is essential for healthcare providers to weigh the benefits and risks when prescribing hormonal therapy to clients.

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