Choice A rationale:

Easy bruising is a common clinical manifestation of hemophilia.

Patients with hemophilia have difficulty forming blood clots, which makes them prone to bleeding into the soft tissues, leading to easy bruising.

This choice is correct.

Choice B rationale:

Hematuria (blood in the urine) is not a typical clinical manifestation of hemophilia.

Hemorrhaging in the urinary tract is uncommon in hemophilia, so this choice is incorrect.

Choice C rationale:

Joint pain and swelling are characteristic clinical manifestations of hemophilia.

Bleeding into the joints can cause pain, swelling, and limited range of motion.

This choice is correct.

Choice D rationale:

Elevated factor VIII levels are not an expected clinical manifestation of hemophilia.

In fact, individuals with hemophilia have reduced levels of factor VIII due to the genetic mutation that causes the condition.

This choice is incorrect.

Choice E rationale:

Spontaneous nosebleeds are a common clinical manifestation of hemophilia.

The fragile blood vessels in the nose can rupture easily, leading to spontaneous nosebleeds.

This choice is correct.