Introduction
Introduction ( 5 Questions)
A nurse is administering ibuprofen, a nonselective COX inhibitor, to a client who has osteoarthritis. What are the expected pharmacologic effects of ibuprofen in this condition?
This is incorrect because ibuprofen also blocks the production of prostaglandins that regulate platelet aggregation. Therefore, ibuprofen can increase the risk of bleeding by inhibiting platelet function².
This is because ibuprofen is a nonselective COX inhibitor, which means it blocks both COX-1 and COX-2 enzymes². COX-1 is responsible for producing prostaglandins that protect the gastric mucosa, regulate platelet aggregation, and maintain renal function². COX-2 is responsible for producing prostaglandins that mediate inflammation, pain, and fever². Therefore, by inhibiting both COX-1 and COX-2, ibuprofen reduces inflammation, pain, fever, and gastric mucosal protection by blocking the production of prostaglandins.
This is incorrect because ibuprofen also blocks the production of prostaglandins that maintain renal function. Therefore, ibuprofen can cause sodium and water retention by impairing renal perfusion and glomerular filtration².
This is incorrect because ibuprofen also blocks the production of prostaglandins that mediate bronchodilation. Therefore, ibuprofen can cause bronchoconstriction by shifting the balance between prostanoids and leukotrienes in favor of leukotrienes².
This is because ibuprofen is a nonselective COX inhibitor, which means it blocks both COX-1 and COX-2 enzymes². COX-1 is responsible for producing prostaglandins that protect the gastric mucosa, regulate platelet aggregation, and maintain renal function². COX-2 is responsible for producing prostaglandins that mediate inflammation, pain, and fever². Therefore, by inhibiting both COX-1 and COX-2, ibuprofen reduces inflammation, pain, fever, and gastric mucosal protection by blocking the production of prostaglandins.
The other options are incorrect because:
A. It reduces inflammation, pain, fever, and platelet aggregation by blocking the production of prostaglandins.
This is incorrect because ibuprofen also blocks the production of prostaglandins that regulate platelet aggregation. Therefore, ibuprofen can increase the risk of bleeding by inhibiting platelet function².
C. It reduces inflammation, pain, fever, and sodium retention by blocking the production of prostaglandins.
This is incorrect because ibuprofen also blocks the production of prostaglandins that maintain renal function. Therefore, ibuprofen can cause sodium and water retention by impairing renal perfusion and glomerular filtration².
D. It reduces inflammation, pain, fever, and bronchoconstriction by blocking the production of prostaglandins.
This is incorrect because ibuprofen also blocks the production of prostaglandins that mediate bronchodilation. Therefore, ibuprofen can cause bronchoconstriction by shifting the balance between prostanoids and leukotrienes in favor of leukotrienes².