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A nurse is administering aspirin (ASA) to a client who has a history of peptic ulcer disease. Which of the following actions should the nurse take?³
Give enteric-coated or buffered aspirin to reduce gastric irritation: Enteric-coated aspirin is designed to resist dissolving and being absorbed in the stomach, so it passes into the small intestine, where it’s absorbed into the bloodstream. The goal is to prevent stomach ulcers and bleeding that can sometimes occur with aspirin use. However, research indicates that enteric-coated aspirin may not be as effective as regular aspirin at reducing blood clot risk. Also, the gastrointestinal benefit of enteric-coated aspirin is minimal to nonexistent. When it comes to rates of ulceration and bleeding, there’s no difference between enteric-coated and regular aspirin¹.
Give aspirin with an antacid to neutralize gastric acid: While antacids can help reduce heartburn and upset stomach that aspirin may cause, they do not prevent the formation of ulcers. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of bleeding, including in the stomach and gastrointestinal tract (digestive tract)⁵.
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that can irritate the stomach lining and increase the risk of ulcers. Proton pump inhibitors (PPIs) and misoprostol are medications that can help protect the stomach lining and reduce the risk of ulcers in people taking NSAIDs. PPIs work by reducing the amount of acid produced by the stomach, while misoprostol helps to replace prostaglandins, which are important for protecting the stomach lining. Giving aspirin with a PPI or misoprostol can help prevent ulcer formation in people with a history of peptic ulcer disease who need to take aspirin.³
Give aspirin with food or milk to decrease gastric absorption: Taking aspirin with food or milk can help reduce stomach irritation caused by aspirin⁷. However, this does not prevent the formation of ulcers in people with a history of peptic ulcer disease.
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that can irritate the stomach lining and increase the risk of ulcers. Proton pump inhibitors (PPIs) and misoprostol are medications that can help protect the stomach lining and reduce the risk of ulcers in people taking NSAIDs. PPIs work by reducing the amount of acid produced by the stomach, while misoprostol helps to replace prostaglandins, which are important for protecting the stomach lining. Giving aspirin with a PPI or misoprostol can help prevent ulcer formation in people with a history of peptic ulcer disease who need to take aspirin.³
The other options are incorrect because:
- A. Give enteric-coated or buffered aspirin to reduce gastric irritation: Enteric-coated aspirin is designed to resist dissolving and being absorbed in the stomach, so it passes into the small intestine, where it’s absorbed into the bloodstream. The goal is to prevent stomach ulcers and bleeding that can sometimes occur with aspirin use. However, research indicates that enteric-coated aspirin may not be as effective as regular aspirin at reducing blood clot risk. Also, the gastrointestinal benefit of enteric-coated aspirin is minimal to nonexistent. When it comes to rates of ulceration and bleeding, there’s no difference between enteric-coated and regular aspirin¹.
- B. Give aspirin with an antacid to neutralize gastric acid: While antacids can help reduce heartburn and upset stomach that aspirin may cause, they do not prevent the formation of ulcers. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of bleeding, including in the stomach and gastrointestinal tract (digestive tract)⁵.
- D. Give aspirin with food or milk to decrease gastric absorption: Taking aspirin with food or milk can help reduce stomach irritation caused by aspirin⁷. However, this does not prevent the formation of ulcers in people with a history of peptic ulcer disease.