More questions on this topic
More questions on this topic ( 10 Questions)
A nurse is preparing to administer a medication that undergoes extensive first-pass metabolism. What route of administration should be used?
Oral administration would result in lower bioavailability due to first-pass metabolism.
First-pass metabolism refers to the metabolism of a drug by the liver before it reaches systemic circulation. Drugs that undergo extensive first-pass metabolism have a lower bioavailability when administered orally because a significant portion of the drug is metabolized before it reaches systemic circulation. Intravenous administration bypasses first-pass metabolism and delivers the drug directly into systemic circulation.
Subcutaneous administration may also be subject to first-pass metabolism.
Intramuscular administration may also be subject to first-pass metabolism.
First-pass metabolism refers to the metabolism of a drug by the liver before it reaches systemic circulation. Drugs that undergo extensive first-pass metabolism have a lower bioavailability when administered orally because a significant portion of the drug is metabolized before it reaches systemic circulation. Intravenous administration bypasses first-pass metabolism and delivers the drug directly into systemic circulation.
a. Oral administration would result in lower bioavailability due to first-pass metabolism.
c. Subcutaneous administration may also be subject to first-pass metabolism.
d. Intramuscular administration may also be subject to first-pass metabolism.