More questions on this topic

More questions on this topic ( 10 Questions)

A nurse is preparing to administer a medication that undergoes extensive first-pass metabolism. What route of administration should be used?



Correct Answer: B

First-pass metabolism refers to the metabolism of a drug by the liver before it reaches systemic circulation. Drugs that undergo extensive first-pass metabolism have a lower bioavailability when administered orally because a significant portion of the drug is metabolized before it reaches systemic circulation. Intravenous administration bypasses first-pass metabolism and delivers the drug directly into systemic circulation.

a. Oral administration would result in lower bioavailability due to first-pass metabolism.

c. Subcutaneous administration may also be subject to first-pass metabolism.

d. Intramuscular administration may also be subject to first-pass metabolism.




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