More questions on this topics
More questions on this topics ( 26 Questions)
A nurse is caring for a client who has chronic hepatitis C and reports taking acetaminophen daily for headaches. The nurse should monitor the client for which of the following adverse effects?
Acetaminophen (APAP) is a common cause of drug-induced liver injury and can lead to hepatic necrosis, especially in patients who have chronic hepatitis C. APAP is metabolized by the liver and produces a toxic intermediate called N-acetyl-p-benzoquinone imine (NAPQI), which can deplete glutathione and damage hepatocytes. Patients who have chronic hepatitis C may have reduced glutathione levels and increased oxidative stress, making them more susceptible to APAP toxicity.
This is wrong because APAP does not cause pulmonary fibrosis.
Pulmonary fibrosis is a chronic lung disease that involves scarring of the lung tissue and impaired gas exchange. Some drugs that can cause pulmonary fibrosis are amiodarone, bleomycin, methotrexate, and nitrofurantoin.
This is wrong because APAP does not cause pancreatitis.
Pancreatitis is an inflammation of the pancreas that can result from gallstones, alcohol abuse, hypertriglyceridemia, hypercalcemia, infections, trauma, or certain medications.
Some drugs that can cause pancreatitis are azathioprine, valproic acid, didanosine, and pentamidine.
This is wrong because APAP does not cause cardiac dysrhythmias.
Cardiac dysrhythmias are abnormal heart rhythms that can result from electrolyte imbalances, ischemia, myocardial infarction, heart failure, congenital defects, or certain medications.
Some drugs that can cause cardiac dysrhythmias are digoxin, quinidine, sotalol, and erythromycin.
The correct answer is choice A. Hepatic necrosis. Acetaminophen (APAP) is a common cause of drug-induced liver injury and can lead to hepatic necrosis, especially in patients who have chronic hepatitis C. APAP is metabolized by the liver and produces a toxic intermediate called N-acetyl-p-benzoquinone imine (NAPQI), which can deplete glutathione and damage hepatocytes. Patients who have chronic hepatitis C may have reduced glutathione levels and increased oxidative stress, making them more susceptible to APAP toxicity.
Choice B. Pulmonary fibrosis is wrong because APAP does not cause pulmonary fibrosis.
Pulmonary fibrosis is a chronic lung disease that involves scarring of the lung tissue and impaired gas exchange. Some drugs that can cause pulmonary fibrosis are amiodarone, bleomycin, methotrexate and nitrofurantoin.
Choice C. Pancreatitis is wrong because APAP does not cause pancreatitis.
Pancreatitis is an inflammation of the pancreas that can result from gallstones, alcohol abuse, hypertriglyceridemia, hypercalcemia, infections, trauma or certain medications.
Some drugs that can cause pancreatitis are azathioprine, valproic acid, didanosine and pentamidine.
Choice D. Cardiac dysrhythmias is wrong because APAP does not cause cardiac dysrhythmias.
Cardiac dysrhythmias are abnormal heart rhythms that can result from electrolyte imbalances, ischemia, myocardial infarction, heart failure, congenital defects or certain medications.
Some drugs that can cause cardiac dysrhythmias are digoxin, quinidine, sotalol and erythromycin.