Paget’s Disease
Paget’s Disease ( 45 Questions)
Which cell type is primarily responsible for the increased bone resorption seen in Paget's disease?
Osteocytes: Osteocytes are mature bone cells embedded in the bone matrix. While they play a role in maintaining bone health, they are not directly responsible for bone resorption.
Osteoblasts: Osteoblasts are bone-forming cells. In Paget's disease, they attempt to repair the resorbed bone but their activity is disordered, leading to structurally abnormal bone formation.
Osteoclasts are the primary cell type responsible for bone resorption in Paget's disease. These cells become overactive, leading to excessive bone breakdown, which is a hallmark of the condition.
Osteoprogenitor cells: Osteoprogenitor cells are undifferentiated cells that can differentiate into osteoblasts. They are not directly involved in the increased bone resorption seen in Paget's disease.
Osteoclasts are the primary cell type responsible for bone resorption in Paget's disease. These cells become overactive, leading to excessive bone breakdown, which is a hallmark of the condition.
a. Osteocytes: Osteocytes are mature bone cells embedded in the bone matrix. While they play a role in maintaining bone health, they are not directly responsible for bone resorption.
b. Osteoblasts: Osteoblasts are bone-forming cells. In Paget's disease, they attempt to repair the resorbed bone but their activity is disordered, leading to structurally abnormal bone formation.
d. Osteoprogenitor cells: Osteoprogenitor cells are undifferentiated cells that can differentiate into osteoblasts. They are not directly involved in the increased bone resorption seen in Paget's disease.