Ankylosing Spondylitis
Ankylosing Spondylitis ( 15 Questions)
What explanation by the nurse is correct?
"The inflammation in Ankylosing Spondylitis primarily occurs in the peripheral joints." Rationale: This statement is incorrect. Ankylosing Spondylitis primarily affects the axial skeleton, including the spine and sacroiliac joints. Peripheral joint involvement is less common and usually occurs in the later stages of the disease.
"Immune cells infiltrate muscles, leading to muscle wasting in Ankylosing Spondylitis." Rationale: This statement is not accurate. Ankylosing Spondylitis primarily involves inflammation of the spine and sacroiliac joints, rather than muscle tissue. Muscle wasting is not a characteristic feature of AS.
"Pro-inflammatory cytokines like TNF-α and IL-17 contribute to inflammation in Ankylosing Spondylitis." Rationale: This statement is correct. Ankylosing Spondylitis is associated with increased levels of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17). These cytokines play a key role in the inflammation and tissue damage seen in AS.
"The chronic inflammation in Ankylosing Spondylitis causes cartilage regeneration." Rationale: This statement is not accurate. Chronic inflammation in AS can lead to structural damage and fusion of the spinal vertebrae (ankylosis), but it does not promote cartilage regeneration.
Choice A rationale:
"The inflammation in Ankylosing Spondylitis primarily occurs in the peripheral joints." Rationale: This statement is incorrect.
Ankylosing Spondylitis primarily affects the axial skeleton, including the spine and sacroiliac joints.
Peripheral joint involvement is less common and usually occurs in the later stages of the disease.
Choice B rationale:
"Immune cells infiltrate muscles, leading to muscle wasting in Ankylosing Spondylitis." Rationale: This statement is not accurate.
Ankylosing Spondylitis primarily involves inflammation of the spine and sacroiliac joints, rather than muscle tissue.
Muscle wasting is not a characteristic feature of AS.
Choice C rationale:
"Pro-inflammatory cytokines like TNF-α and IL-17 contribute to inflammation in Ankylosing Spondylitis." Rationale: This statement is correct.
Ankylosing Spondylitis is associated with increased levels of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17).
These cytokines play a key role in the inflammation and tissue damage seen in AS.
Choice D rationale:
"The chronic inflammation in Ankylosing Spondylitis causes cartilage regeneration." Rationale: This statement is not accurate.
Chronic inflammation in AS can lead to structural damage and fusion of the spinal vertebrae (ankylosis), but it does not promote cartilage regeneration.