Antimicrobial resistance
Antimicrobial resistance ( 4 Questions)
A nurse is educating a client with tuberculosis about the importance of adhering to the prescribed regimen of rifampin, isoniazid, pyrazinamide, and ethambutol for six months.
The nurse should explain that this combination of drugs is necessary to:
This means that the combination of drugs reduces the chances of the bacteria becoming resistant to one or more of the drugs, which would make the treatment ineffective.
Choice B is wrong because “enhance the selective toxicity of each drug” means that the drugs would target only the bacteria and not harm the host cells, which is not the main reason for using a combination of drugs.
Choice C is wrong because “increase the penetration of drugs into the lungs” means that the drugs would reach the site of infection more easily, which is not the main reason for using a combination of drugs.
Choice D is wrong because “reduce the adverse effects of each drug” means that the drugs would have less side effects when used together, which is not the main reason for using a combination of drugs. In fact, some of these drugs can have serious side effects such as liver damage, vision loss, or nerve damage.
This means that the combination of drugs reduces the chances of the bacteria becoming resistant to one or more of the drugs, which would make the treatment ineffective.
Choice B is wrong because “enhance the selective toxicity of each drug” means that the drugs would target only the bacteria and not harm the host cells, which is not the main reason for using a combination of drugs.
Choice C is wrong because “increase the penetration of drugs into the lungs” means that the drugs would reach the site of infection more easily, which is not the main reason for using a combination of drugs.
Choice D is wrong because “reduce the adverse effects of each drug” means that the drugs would have less side effects when used together, which is not the main reason for using a combination of drugs. In fact, some of these drugs can have serious side effects such as liver damage, vision loss, or nerve damage.
Normal ranges for rifampin are 8-24 mcg/mL, for isoniazid are 1-6 mcg/mL, for pyrazinamide are 20-60 mcg/mL, and for ethambutol are 2-6 mcg/mL.