Choice A rationale:

A negative mammogram is not a requirement of the iPLEDGE program. Mammograms are used to screen for breast cancer and are not related to isotretinoin therapy.

Choice B rationale:

Regular Papanicolaou tests, which screen for cervical cancer, are not a requirement of the iPLEDGE program. These tests are not related to isotretinoin therapy.

Choice C rationale:

There is no requirement for clients to begin a daily supplement of vitamin A prior to initiating therapy. In fact, taking additional vitamin A while on isotretinoin can increase the risk of vitamin A toxicity.

Choice D rationale:

Sexually active female clients must use two forms of birth control during treatment. This is because isotretinoin can cause severe birth defects.