Factors Affecting Drug Interactions

Factors Affecting Drug Interactions ( 10 Questions)

A patient has been prescribed two drugs with one being an inverse agonist and another being a partial agonist at the same receptor. What will be their combined effect? 



Correct Answer: D

An inverse agonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity.

a. Increasing inverse agonist’s action will not occur as an inverse agonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity. 

b. Decreasing the inverse agonist’s action will not occur as an inverse agonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity. 

c. No change will not occur as an inverse agonist will increase a partial agonist’s action by competing for binding at the same receptor and decreasing the basal activity. 

d. Increasing partial agonist’s action will occur due to competition for binding at the same receptor by an inverse agonist and decreasing the basal activity.




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