Mixed Agonists/Antagonists

Mixed Agonists/Antagonists ( 5 Questions)

A nurse is preparing to administer butorphanol (Stadol) to a client who has severe pain after surgery. The client tells the nurse that he has been taking morphine (Duramorph) for several months for chronic back pain.
Which of the following responses should the nurse make?



Correct Answer: A

You might experience some withdrawal symptoms when you receive this medication. This is because butorphanol (Stadol) is an agonist-antagonist opioid that can cause abstinence syndrome in opioid-dependent clients. Abstinence syndrome is a group of symptoms that occur when a person who is physically dependent on opioids suddenly stops taking them. Some of the symptoms include vomiting, abdominal cramps, hypertension, fever, and anxiety.

Choice B is wrong because you will not need a higher dose of this medication to achieve pain relief. Butorphanol (Stadol) is a potent analgesic that can provide effective pain relief at lower doses than morphine.

Choice C is wrong because you can take this medication if you have a history of opioid dependence, but you should be monitored for signs of withdrawal and adverse effects. Butorphanol (Stadol) has a lower risk of abuse and respiratory depression than morphine.

Choice D is wrong because you will not have less risk of respiratory depression with this medication. Butorphanol (Stadol) can still cause respiratory depression, especially if taken with other CNS depressants or at high doses. You should have your respiratory rate checked before and after receiving this medication, and an opioid antagonist such as naloxone should be available in case of overdose.




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