Choice A rationale:

Radiation therapy.

Rationale: Radiation therapy is not commonly used as the primary treatment modality for Osteosarcoma.

While it may be used in certain situations to shrink tumors or manage symptoms, the primary treatment approach for Osteosarcoma typically involves a combination of surgery and chemotherapy.

Choice B rationale:

Chemotherapy.

Rationale: This statement is accurate.

Chemotherapy is commonly used as a part of the multimodal treatment approach for Osteosarcoma.

It is usually administered before surgery to shrink the tumor and after surgery to target any remaining cancer cells.

Chemotherapy drugs like methotrexate and cisplatin are commonly used in Osteosarcoma treatment protocols.

Choice C rationale:

Hormone therapy.

Rationale: Hormone therapy is not a standard treatment for Osteosarcoma.

Osteosarcoma is not a hormone-sensitive cancer, so hormone therapy is not effective in its management.

Choice D rationale:

Physical therapy.

Rationale: Physical therapy may be used as part of the comprehensive care plan for Osteosarcoma patients, especially after surgery or during the recovery phase.

However, it is not a primary treatment modality for the disease itself.