Sickle Cell Disease
Sickle Cell Disease ( 15 Questions)
Select all that apply:
Patients with sickle cell disease (SCD) have an increased risk of infection due to the compromised immune function associated with the disease. SCD can lead to functional asplenia, making individuals more susceptible to infections, particularly those caused by encapsulated bacteria.
Hypoxia (lack of oxygen) and ischemia (reduced blood flow) are common complications of SCD. The sickle-shaped red blood cells can obstruct blood vessels, leading to reduced oxygen delivery to tissues (hypoxia) and tissue damage due to impaired blood flow (ischemia)
Blood clot formation is a known complication of SCD. The altered shape of sickle cells can lead to the blockage of blood vessels, causing painful vaso-occlusive crises and increasing the risk of clot formation.
This choice is incorrect. Reduced risk of stroke is not associated with SCD. In fact, individuals with SCD may have an increased risk of stroke due to the potential for vasculopathy and clot formation.
Reduced adhesion of red blood cells (RBCs) to the endothelium is not a typical feature of SCD. In fact, the adhesion of sickle cells to the endothelium is one of the pathophysiological mechanisms leading to vaso-occlusive events in SCD.
Choice A rationale:
Patients with sickle cell disease (SCD) have an increased risk of infection due to the compromised immune function associated with the disease.
SCD can lead to functional asplenia, making individuals more susceptible to infections, particularly those caused by encapsulated bacteria.
Choice B rationale:
Hypoxia (lack of oxygen) and ischemia (reduced blood flow) are common complications of SCD.
The sickle-shaped red blood cells can obstruct blood vessels, leading to reduced oxygen delivery to tissues (hypoxia) and tissue damage due to impaired blood flow (ischemia)
Choice C rationale:
Blood clot formation is a known complication of SCD.
The altered shape of sickle cells can lead to the blockage of blood vessels, causing painful vaso-occlusive crises and increasing the risk of clot formation.
Choice D rationale:
This choice is incorrect.
Reduced risk of stroke is not associated with SCD.
In fact, individuals with SCD may have an increased risk of stroke due to the potential for vasculopathy and clot formation.
Choice E rationale:
Reduced adhesion of red blood cells (RBCs) to the endothelium is not a typical feature of SCD.
In fact, the adhesion of sickle cells to the endothelium is one of the pathophysiological mechanisms leading to vaso-occlusive events in SCD.