Blood transfusion
Blood transfusion ( 30 Questions)
What complication could be responsible for these symptoms?
Transfusion-associated graft-versus-host disease (TA-GVHD) typically presents with symptoms of fever, rash, diarrhea, and pancytopenia 1 to 6 weeks after transfusion. It is a delayed reaction, but it does not cause epistaxis, hematuria, and menorrhagia, which are bleeding symptoms. Therefore, it is an unlikely choice for this scenario.
Transfusion-related immunomodulation (TRIM) is a theory that blood transfusions may affect the immune system, but it does not typically present with the specific bleeding symptoms described in the scenario. TRIM is more concerned with the immunosuppressive effects of transfusions.
Post-transfusion purpura is a rare condition that occurs 5 to 12 days after a transfusion. It is characterized by sudden severe thrombocytopenia (low platelet count) and bleeding symptoms, which can include epistaxis (nosebleeds), hematuria (blood in the urine), and menorrhagia (excessive menstrual bleeding) This aligns with the symptoms described in the scenario, making it the most likely cause.
Viral infections can be a complication of blood transfusions, but they do not typically present with these specific bleeding symptoms within 7 days after the transfusion. Viral infections may cause a broader range of symptoms and have a longer incubation period.
Choice A rationale:
Transfusion-associated graft-versus-host disease (TA-GVHD) typically presents with symptoms of fever, rash, diarrhea, and pancytopenia 1 to 6 weeks after transfusion.
It is a delayed reaction, but it does not cause epistaxis, hematuria, and menorrhagia, which are bleeding symptoms.
Therefore, it is an unlikely choice for this scenario.
Choice B rationale:
Transfusion-related immunomodulation (TRIM) is a theory that blood transfusions may affect the immune system, but it does not typically present with the specific bleeding symptoms described in the scenario.
TRIM is more concerned with the immunosuppressive effects of transfusions.
Choice C rationale:
Post-transfusion purpura is a rare condition that occurs 5 to 12 days after a transfusion.
It is characterized by sudden severe thrombocytopenia (low platelet count) and bleeding symptoms, which can include epistaxis (nosebleeds), hematuria (blood in the urine), and menorrhagia (excessive menstrual bleeding)
This aligns with the symptoms described in the scenario, making it the most likely cause.
Choice D rationale:
Viral infections can be a complication of blood transfusions, but they do not typically present with these specific bleeding symptoms within 7 days after the transfusion.
Viral infections may cause a broader range of symptoms and have a longer incubation period.