Pharmacokinetics
Pharmacokinetics ( 10 Questions)
A nurse is preparing to administer a lipophilic medication to a client with a high body fat percentage. What should the nurse consider?
Lipophilic medications are soluble in fat and can accumulate in adipose tissue, reducing their concentration in plasma and potentially reducing their therapeutic effect. A client with a high body fat percentage may require a higher dose of a lipophilic medication to achieve therapeutic levels.
The client may require a higher, not lower, dose of the medication due to accumulation in adipose tissue.
More frequent dosing may not be necessary if an appropriate dose is administered.
The client’s body fat percentage can affect pharmacokinetics by altering distribution of lipophilic medications.
Lipophilic medications are soluble in fat and can accumulate in adipose tissue, reducing their concentration in plasma and potentially reducing their therapeutic effect. A client with a high body fat percentage may require a higher dose of a lipophilic medication to achieve therapeutic levels.
b. The client may require a higher, not lower, dose of the medication due to accumulation in adipose tissue.
c. More frequent dosing may not be necessary if an appropriate dose is administered.
d. The client’s body fat percentage can affect pharmacokinetics by altering distribution of lipophilic medications.