Pharmacokinetics
Pharmacokinetics ( 10 Questions)
A nurse is preparing to administer a weakly acidic medication to a client with an elevated gastric pH due to antacid use. What should the nurse consider?
The medication will have decreased, not increased, absorption in an alkaline environment due to increased ionization.
Weakly acidic medications are more readily absorbed in an acidic environment because they are more likely to be in their non-ionized, lipid-soluble form which can easily cross cell membranes and enter systemic circulation. An elevated gastric pH due to antacid use can reduce absorption of weakly acidic medications by increasing ionization and reducing lipid solubility.
The antacid can affect absorption by altering gastric pH and increasing ionization of weakly acidic medications.
The antacid can affect absorption but does not directly affect excretion of weakly acidic medications.
Weakly acidic medications are more readily absorbed in an acidic environment because they are more likely to be in their non-ionized, lipid-soluble form which can easily cross cell membranes and enter systemic circulation. An elevated gastric pH due to antacid use can reduce absorption of weakly acidic medications by increasing ionization and reducing lipid solubility.
a. The medication will have decreased, not increased, absorption in an alkaline environment due to increased ionization.
c. The antacid can affect absorption by altering gastric pH and increasing ionization of weakly acidic medications.
d. The antacid can affect absorption but does not directly affect excretion of weakly acidic medications.