Pharmacokinetics
Pharmacokinetics ( 10 Questions)
A nurse is preparing to administer a medication that is highly protein bound.What should be considered when administering this drug to a client with hypoalbuminemia?
Medications that are highly protein bound bind to plasma proteins such as albumin, reducing their free fraction and potentially reducing their therapeutic effect.A client with hypoalbuminemia may have an increased free fraction of a highly protein-bound medication due to reduced protein binding, potentially increasing its therapeutic effect.
The client may have an increased, not decreased, free fraction of the drug due to reduced protein binding.
An increased volume of distribution may occur if protein binding is reduced, but this is not directly related to hypoalbuminemia.
The client’s albumin levels can affect pharmacokinetics by altering protein binding of highly protein-bound medications.
Medications that are highly protein bound bind to plasma proteins such as albumin, reducing their free fraction and potentially reducing their therapeutic effect.A client with hypoalbuminemia may have an increased free fraction of a highly protein-bound medication due to reduced protein binding, potentially increasing its therapeutic effect.
b.The client may have an increased, not decreased, free fraction of the drug due to reduced protein binding.
c.An increased volume of distribution may occur if protein binding is reduced, but this is not directly related to hypoalbuminemia.
d.The client’s albumin levels can affect pharmacokinetics by altering protein binding of highly protein-bound medications.